I am a
proud distributor of Protandim, a revolutionary herbal supplement that has been
proven in peer-reviewed, human clinical trials to reduce measures of oxidative
stress by an average of 40% in every person, every time. For this reason and more, I believe
that Protandim represents a true scientific breakthrough; a revolutionary
nutritional technology that has the potential to make much of what came before
it obsolete. No more mega antioxidant therapy. No more "super
juices." Protandim is a true "replacement technology" in the
wide world of supplements.
What is Oxidative Stress?
In this day and age, most of us have heard of "free radicals" and "antioxidants." Free radicals are rogue molecules that cause damage to healthy cells. Over time, increased generation of free radicals causes oxidative stress, which can contribute to aging and disease. Oxidative stress in the body is analogous to the rusting of a car. The more oxidative exposure, the more things are going to break down, and that's true whether we're talking about cars or people.
Free radicals are not all bad, of course. We need them for proper immune function and for fighting infections, for instance. But when the production of oxidants (free radicals) outstrips the body's anti-oxidant production, aging and degeneration are sure to follow.
problem. Nearly everyone produces too many free radicals. The majority of us have too much
oxidative stress. And it only gets worse with age and with exposure to
environmental, physical, and emotional stressors. The average person produces
300 sextillion free radicals every day. That's 300 with 21 zeros behind
300,000,000,000,000,000,000,000 free radicals per day, every day.
wonder that scientists have linked oxidative stress with literally hundreds of
human diseases, including cancer, heart disease, Alzheimer's, and more. We are
assaulted with 300 sextillion free radicals per day, and the number goes up
with age and with stress of any
world's top scientists are definitely aware of how important the connection is
between oxidative stress and disease. If you check out Pubmed.gov (the
government database of biomedical research), you'll find that oxidative stress
has been a very hot topic in recent years. Typing in "oxidative
stress" on PubMed returns an astounding 98,945
references to oxidative stress in the scientific literature! And the list is growing every
day. Click the image below to see for yourself.
You can see by now that free radicals are a big deal. You might also understand now why "antioxidant" has become such a buzzword in our culture. There can be little doubt that antioxidants are important, since they're the only things standing in the way of a vast army of unrelenting free radicals and our easily damaged cells. Antioxidants are now popping up on labels everywhere – on cereal boxes, baby food, supplements, "superfood" fruit juices, and more. The idea is that if you can just eat enough antioxidants in your diet, maybe you can offset – or even reverse – oxidative stress, and thus aging and disease.
it's true that a diet rich in whole-food antioxidants is good for you. There's
plenty of research showing the advantages of consuming dietary antioxidant
foods like blueberries, chocolate, and red wine. However, there's one little
problem. Remember that number I mentioned earlier? The one with all the zeroes?
300,000,000,000,000,000,000,000 Free Radicals.
Per day. Every day.
problem is that the antioxidants you eat (known as direct, or
"exogenous" antioxidants), such as vitamin C or vitamin E, have very
short-lived effectiveness. Each antioxidant molecule is able to eliminate around
one free radical. Then it's done. One molecule of vitamin C takes out one free
radical molecule. Understanding this, it's absolutely staggering to think of
how many exogenous antioxidants one would have to consume each day in order to neutralize
300 sextillion free radicals.
To put it
in perspective, you would have to consume 15 lbs of chocolate, or 375 oranges,
or 87 glasses of red wine, or 120 vitamin C capsules (500 mg/cap).
No one can
do this, of course. And it's a good thing that the body doesn't rely on only exogenous
antioxidants. It turns out that the body also makes its own antioxidants. A few
of the most prominent ones are known as superoxide dismutase (SOD), catalase, and
glutathione peroxidase. These are super antioxidants, because they work a
whole lot better than the antioxidants we eat. While a molecule vitamin C, for
instance, can neutralize only one free radical molecule, one molecule of the
body's self-made (endogenous) antioxidant SOD can neutralize one million free radicals. Impressed? But it gets better. The
body's endogenous antioxidants neutralize one million free radicals per second, every second of every day.
antioxidants you eat neutralize free radicals at a rate of
antioxidants you make neutralize free radicals at a rate of
you rather focus on eating more antioxidants, or on finding ways to help your body
produce more of its own antioxidants? The second option is literally one million times more effective.
with a Good Thing?
inevitable question is, "If the body makes such great antioxidants, why is
oxidative stress even a problem, and why do we need to do anything about it?"
is simply that as we age, we become less efficient at producing these
antioxidant enzymes. Meanwhile, free radical production simultaneously
increases independently of the reduced antioxidant production. So we not only
have increased free radicals to deal with, but we become less equipped to deal
with them as time goes on.
reality is that we live in an increasingly toxic world, and each of us are
unavoidably inundated with chemicals, pesticides, heavy metals, and other
environmental toxins that undoubtedly increase oxidative stress. Thus, while
oxidative stress increases with age, it is not just the
aged who are affected by oxidative stress. Young people and even small children
are susceptible to oxidative damage due to the impact of the toxic world we
words, for various reasons our bodies can't keep up with the amount of free
radicals that we're exposed to on a daily basis. We're falling short of
producing the amount of antioxidant enzymes that we really need for living in
today's world. And this is why eating blueberries, raspberries, chocolate, and
red wine can be somewhat helpful. It helps to offset some of the free radical
damage that the body can't keep up with on its own. But it's not the only way to fight back, and it's certainly not the best way.
It doesn't even come close to dealing with the problem in a seriously
the Power of Your Genes
better way of dealing with this massive problem of oxidative stress? Instead of
consuming obscene amounts of antioxidant supplements or foods, imagine if you
could just "tell" your genes to start producing optimal amounts of
those endogenous antioxidants we talked about earlier: SOD, catalase, and
glutathione. This would definitely be the preferable option.
does exactly that. Its combination of five natural ingredients activates a
transcription factor (a special kind of signaling protein) called Nrf2 that
tells your genes to increase their production of antioxidant,
anti-inflammatory, and anti-fibrotic enzymes!
effect is so profound that a peer-reviewed study in 2006 showed that Protandim could reduce
levels of oxidative stress in the body down to the level of a 20 year old! By
the end of the study, the researchers could no longer tell a difference between
the levels of oxidative stress of the 20 year old and that of the 80 year old!
In other words, do you remember the age-dependent increase in oxidative stress
that I mentioned earlier? Protandim
completely eliminated that. In 30 days.
causes a drop in oxidative stress by an average of 40% in 30 days, in every
person, every single time. No other supplement or drug in the world has ever
been shown to do this.
So was I. As a naturopathic doctor, I work in a
field that is rife with charlatans, unproven claims, and worthless products. It
has always been my goal to show my clients that “alternative medicine” can be
just as science-based and rational as any other legitimate discipline.
So when I was introduced to Protandim, my
immediate response was skepticism. Why? Because that’s my default
predisposition when it comes to evaluating new supplements. And I think that’s
a healthy predisposition to have in this business. It has to prove itself to me
and meet my criteria for a promising preventative or therapeutic agent before I
will give it my endorsement.
As a skeptic, I checked out Protandim as
objectively as possible. In a market that is absolutely bloated with
antioxidant and anti-aging type supplements, I honestly wasn’t too thrilled at
the prospect of looking into yet another one, and I wasn’t expecting that I
would find much, if anything, that was new or uniquely useful.
Boy was I wrong.
On pubmed.gov, I found 10 peer-reviewed studies
on Protandim. Not on the individual ingredients, but on the actual product
itself, with the name of the supplement right in the studies.
Almost all of this research was funded, not by
LifeVantage (the company that makes Protandim), but by the universities and
institutions that were actually conducting the research. So almost all of the
studies on Protandim were independently-funded, and the conclusions of these
studies were overwhelmingly favorable:
- Protandim eliminated the age-related increase in cell-aging factors by increasing the body's antioxidant defenses. After just 30 days, oxidative stress declined by an average of 40%. The super antioxidants SOD and catalase increased by an average of 30% and 54%, respectively. (Free Radical Biology & Medicine, Jan. 15, 2006)
- Protandim decreased skin tumor incidence and multiplicity by 33 percent and 57 percent, respectively, and may be a novel approach to chemoprevention. (Enzyme Research, March 23, 2011)
- Protandim significantly increased antioxidant enzyme activity in veins while reducing free radical levels, lipid peroxidation and intimal proliferation. Protandim blocked intimal hyperplasia (i.e. it blocked the over-proliferation of cells that line the vessel wall, a common adverse event that limits the effectiveness of vascular surgery, stenting, etc.). (Free Radical Biology & Medicine, March 15, 2011)
- Protandim decreased oxidative stress by an average of 48 percent, reduced osteopontin (a glycoprotein involved in many diseases) by 57 percent, increased beneficial protective plasma PON1 activity by 35% and reduced fibrosis. (Journal of Deitary Supplements, June 1, 2010)
- Protandim induced antioxidant enzymes and reduced the incidence and multiplicity of skin tumors, and may be practical for cancer prevention. (PLoS One, April 22, 2009)
- Protandim protected animals' hearts by increasing the expression of protective genes and preventing the formation of scar tissue. Those treated with the Protandim experienced strong cardio-protectitive effects. (Circulation, Nov. 17, 2009)
- Protandim increases antioxidant enzymes and may be a practical and potent approach for cancer prevention. The suppression of p53 and induction of MnSOD may play an important role in the tumor suppressive activity of Protandim. (PLoS One, July 30, 2010)
- Protandim produced a 300% increase in glutathione, a key antioxidant and anti-aging factor. The antioxidant enzyme heme oxygenase 1 was also increased, Also, the supplement's patented formula provides a strong synergy much greater than the sum of its parts. (Free Radical Biology & Medicine, Feb. 1, 2009)
- Protandim, a potent composition of highly synergistic
phytochemical Nrf2 activators, significantly modulates genetic expression
and pathways involving not only antioxidant enzymes, but also those
related to colon cancer, cardiovascular disease, and Alzheimer disease.
(Molecular Aspects of Medicine, October 18, 2011)
And not only this, but I discovered that there
are nearly 30 independently-funded studies underway at universities and
institutions around the world. They see the unbelievable potential of
Protandim, and they’re paying to research it with their own money. Some of
- University of Colorado
- Denver Health Medical Center
- Children’s Hospital, Denver
- Virginia Commonwealth University
- Colorado State University
- University of Florida
- University of Kentucky
- University of Michigan
- Louisiana State University
- Ohio State University
- Vanderbilt University
- Glamorgan University, Wales
- Sahlgrenska University Hospital, Goteborg, Sweden
- University Hospital, Brno, Czech Republic
- Mexican Institute of Social Security, Mexico City
I wasn’t the only one who was skeptical at first.
When the broadcasting empire ABC caught wind of the patent claims of Protandim
(of which there are now four), they decided to send investigative reporter John
Quiñones to set the record straight.
Quiñones subjected himself to blood testing to
measure his levels of oxidative stress. Would Protandim do what the patents
claimed it could do? After just two weeks, he tested again.
The result? His
levels of oxidative stress fell by 45%. This is precisely what the patents
claim, and is exactly within the range we would predict based on the human
clinical trial, where oxidative stress was reduced by an average of 40%.
In a separate interview, Quiñones also reported
subjective improvements after 2 weeks on Protandim:
am sleeping better – I feel a lot better – and also energized when I wake up.” (Extra, 2005)
But don’t take my word for it. Watch the
incredible ABC Primetime investigation here:
Wanting to be thorough, I decided to do a little experiment of my own. I wanted to see firsthand if Protandim would reduce oxidative stress in one of my clients. She had a serum TBARS test done, the same type of test that was used in the original research. Here are the results prior to starting the Protandim:
As you can see, the lipid peroxides (TBARS) are slightly above average, indicating increasing levels of oxidative stress.
A little over 30 days later, we ran another TBARS test. Same exact person, same exact lab. Here are the results:
As you can see, oxidative stress has plummeted! In just over 30 days, oxidative stress declined by 46%. How's that for proof?
Once I saw the research, watched the ABC investigation, talked to numerous people who were using the product (including other
practitioners), and did my own before/after testing, I knew that this was something I needed for myself, for my
family, and for my clients.
This supplement is revolutionary, and it is
credible. Did I mention that the formulator of Protandim is none other than Dr.
Joe McCord, the discoverer of superoxide
dismutase, and the father of the field of free radical biology? In 1997 he
won the Elliott Cresson Medal for his discovery of free radical reactions in
living organisms. Dr. McCord has been researching free radicals for over 40
years, and has published 138 peer-reviewed papers in the scientific literature. Definitely not a “fly by night” scientist looking to make a quick buck
on a hyped up supplement.
Do you want to reduce your levels of oxidative
stress? Here’s a list of conditions that are associated with oxidative stress:
Benign Prostatic Hyperplasia (BPH)
Carpal Tunnel Syndrome
Childhood Neurodevelopmental Disorders
Chronic Fatigue Syndrome
Congestive Heart Failure
Systemic Lupus Erythematosus (SLE)
And the list could go on.
The science shows that Protandim reduces
oxidative stress by 40%, in every person, every time.
Oxidative stress is implicated with all of the
above diseases and over a hundred more.
Will Protandim “cure” or “prevent” diseases
caused by oxidative stress? I certainly can’t make those kinds of claims, and
besides, that kind of science hasn’t been done yet. But are you going to wait
to find out? Again, oxidative stress causes disease, and Protandim dramatically
reduces oxidative stress. If you want to take a supplement that holds enormous
promise in the fight against aging and disease, look no further than Protandim.