Niatab™ 500 tablets, slowly release 500 mg of pure niacin. Sustained release niacin is better tolerated than regular crystalline high-potency niacin supplements. Niatab 500 is a scored uncoated tablet which can be broken in half when lower dosage is desired.
FUNCTIONS
Niacin (vitamin B3) occurs in the body as two metabolically active coenzymes, NAD (nicotinamide adenine dinucleotide) and NADP (NAD phosphate).
The niacin coenzymes NAD and NADP have pervasive roles in energy-related and biosynthetic metabolic processes. At least 200 enzymes depend on these niacin cofactors.
The NAD-dependent enzymes are involved in mostly catabolic, oxidative reactions that release energy from carbohydrate, fat, and protein, whereas the NADP-dependent enzymes more commonly function in biosynthetic pathways of such compounds as fatty acids and steroid hormones.
Independent of its functions as NAD or NADP, niacin is also involved in the regulation of normal blood lipoprotein and cholesterol levels.
Dietary niacin is generally well absorbed and taken up by the liver which converts it to NAD and NADP. Any excess niacin is metabolized by the liver and excreted by the kidneys. Because the liver has a limited capacity to metabolize niacin, high doses of regular, crystalline niacin are often not well tolerated, causing vasodilatory side effects known as skin-flushing and itching. For maximum benefit and fewer side effects, Niatab 500 releases its niacin over a time frame of two to three hours. This way, the niacin is more efficiently utilized by the liver and more evenly distributed to peripheral tissues compared to crystalline niacin. For the same reasons, Niatab 500 can generally be used at somewhat lower doses than crystalline niacin supplements.
INDICATIONS
Niatab 500 tablets may be a useful nutritional adjunct for individuals who wish to increase their intake of niacin without the uncomfortable side effects of skin flushing.
Each scored tablet contains:
Niacin.......500 mg
Ingredients: Niacin USP, vegetable stearine, cellulose, silicon dioxide, magnesium stearate.
Contains no: yeast, corn, wheat, soy, sugar, or other sweeteners, artificial flavors, colors, or preservatives.
Note: Niacin can cause an uncomfortable flushing of the skin within minutes to hours after ingestion. This flush is normal and results from niacin inducing the release of prostaglandin D2 and serotonin from immune system mast cells, thereby leading to vasodilation in the capillaries of the skin. Aspirin reduces this effect through inhibiting prostaglandin D2 and is often helpful during the initial stages of niacin therapy adjustment. Taking niacin with a meal helps to slow the initial release of niacin and may also blunt the flushing effect. Generous hydration is also advantageous. Use high-dose niacin (and aspirin) only under the supervision of your physician.
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